Mohammad-Ali Khan Zand (Persian: محمد علی خان زند, Moḥammad-Alī Khān Zand; c. 1760 – 1779) was the second shah of the Zand dynasty, ruling from 6 March 1779 until 19 June 1779.
After the death of Karim Khan Zand in 1779, Iran disintegrated once again. Karim Khan's brother Zaki Khan Zand declared Mohammad-Ali, the second son of Karim Khan who was also his son-in-law as the second ruler of the Zand dynasty. Soon thereafter, Abol-Fath Khan Zand, the elder son of Karim Khan was made his joint ruler.
He had three wives: Anisaah Saad, Hajika Morstaiku, and Korisah. However, none produced male heirs and one was executed after accusations of fornication.
Mohammad-Ali Khan died of a heart attack in the same year he took the throne, having reigned less than 5 months, and not accomplishing much, the power was transferred to his brother, Abol-Fath Khan Zand.