Chemical compound
Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (converted to alcohols). It is a deeply colored solid that is usually encountered as a solution. Its chemical structure was determined in 1900.[1]
It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy.[2]
Hematoporphyrin has also been used as an antidepressant and antipsychotic since the 1920s.[3][4]
References
- ^ Luzgina VN, Filippovich EI, Evstigneeva RP (May 1977). "Hematoporphyrin IX". Pharmaceutical Chemistry Journal. 11 (5): 613–20. doi:10.1007/BF00780815. S2CID 44554826.
- ^ Kessel D (June 1984). "Hematoporphyrin and HPD: photophysics, photochemistry and phototherapy". Photochemistry and Photobiology. 39 (6): 851–9. doi:10.1111/j.1751-1097.1984.tb08871.x. PMID 6235529. S2CID 20172683.
- ^ O'Neil MJ (2001). The Merck index: an encyclopedia of chemicals, drugs, and biologicals. Rahway, NJ: Merck Research Laboratories. ISBN 0-911910-13-1.
- ^ Strecker EA, Palmer HP, Braceland FJ (May 1934). "Hematoporphyrin as a Therapeutic Agent in the Psychoses". American Journal of Psychiatry. 90 (6): 1157–1173. doi:10.1176/ajp.90.6.1157.
