Santa Marina Salina is a comune (municipality) and one of the main towns on Salina, one of the Aeolian Islands. It is situated in the Metropolitan City of Messina in the Italian region Sicily, located about 140 kilometres (87 mi) northeast of Palermo and about 70 kilometres (43 mi) northwest of Messina.
Santa Marina Salina borders the municipalities of Leni and Malfa.