Serrone (Central Italian: Jo Serone) is a comune (municipality) in the Province of Frosinone in the Italian region Lazio, located in the Monti Ernici area about 50 kilometres (31 mi) east of Rome and about 30 kilometres (19 mi) northwest of Frosinone.
Serrone borders the following municipalities: Arcinazzo Romano, Olevano Romano, Paliano, Piglio, Roiate.