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Corwin Hansch

Corwin Herman Hansch (October 6, 1918 – May 8, 2011)[2] was a professor of chemistry at Pomona College in California. He became known as the 'father of computer-assisted molecule design.'[3]

Education and career

Hansch was born on October 6, 1918, in Kenmare, North Dakota. He earned a BS from the University of Illinois in 1940 and a PhD from New York University in 1944. He briefly worked as a postdoc at the University of Illinois Chicago.

Hansch worked on the Manhattan Project at the University of Chicago and as a group leader at DuPont Nemours in Richland, Washington. In February 1946 he received an academic position at Pomona College, where he taught until 1988.[4][5] Hansch completed sabbaticals at ETH Zurich with Vladimir Prelog and at University of Munich with Rolf Huisgen.[6]

Hansch taught Organic Chemistry for many years at Pomona College, and was known for giving complex lectures without using notes. His course in Physical Bio-Organic Medicinal Chemistry was ground-breaking at an undergraduate level.

Hansch may be best known as the father of the concept of quantitative structure-activity relationship (QSAR), the quantitative correlation of the physicochemical properties of molecules with their biological activities.[7]

He is also noted for the Hansch equation, which is used in

Research Interests:Organic Chemistry; Interaction of organic chemicals with living organisms, Quantitative Structure Activity Relationships (QSAR).

Death

He died of pneumonia on May 8, 2011, in Claremont, California, at 92.[2]

Notes

His research group at Pomona College worked on QSAR studies and in building and expanding the database of chemical and physical data as C-QSAR and Bioloom. His postgraduate associates were Rajni Garg, Cynthia R. D. Selassie, Suresh Babu Mekapati, and Alka Kurup.

The Journal of Computer-Aided Molecular Design carried four obituaries (as found in a Pubmed personal subject [ps] search).[8][9][10][6]

Among his students at Pomona was Jennifer Doudna, co-recipient of the 2020 Nobel Prize in Chemistry. Doudna has credited Hansch as an influence.[11]

Bibliography

A preliminary search in WorldCat and in PubMed, two among many relevant bibliographic and citation indexes, shows the following:

The Pomona College Archives holds reprints of Hansch's articles published between 1962 and 2009 in addition to other materials.[3]

See also

References

  1. ^ Coats, Eugene; Seydel, Joachim; Leo, Albert (1988). "Corwin Hansch. The Pioneer of QSAR". Quantitative Structure-Activity Relationships. 7 (3): 119–120. doi:10.1002/qsar.19880070302.
  2. ^ a b Maugh, Thomas H. [II] (May 31, 2011). "Corwin Hansch dies at 92; scientist whose advances led to new drugs and chemicals". Los Angeles Times. Retrieved 5 August 2016.
  3. ^ a b Weber, Jamie (2013). "Guide to the Corwin Hansch Collection" (PDF). Pomona College Archives. Claremont, CA 91711. p. 3. Retrieved 5 August 2016.
  4. ^ "1975 Tolman Award Medalist, Dr. Corwin Hansch, Carnegie Professor of Chemistry, Pomona College". Southern California Section of the American Chemical Society. 22 August 2013.
  5. ^ Kendall, Mark. "In Memoriam: Corwin H. Hansch | Pomona College Magazine". Retrieved 2022-08-08.
  6. ^ a b Selassie, Cynthia Rachel (June 21, 2011). "Obituary: Corwin H. Hansch". J Comput Aided Mol Des. 25 (6): 493–494. Bibcode:2011JCAMD..25..493S. doi:10.1007/s10822-011-9445-x. PMID 21691812. S2CID 207165325.
  7. ^ Hansch, Corwin (1993-04-01). "Quantitative structure-activity relationships and the unnamed science". Accounts of Chemical Research. 26 (4): 147–153. doi:10.1021/ar00028a003. ISSN 0001-4842.
  8. ^ Martin, Yvonne C (Jun 29, 2011). "Remembrances of Corwin Hansch". J Comput Aided Mol Des. 25 (6): 519–523. Bibcode:2011JCAMD..25..519M. doi:10.1007/s10822-011-9452-y. PMID 21713458. S2CID 35854016.
  9. ^ Martin, Yvonne C; Stouch, Terry (June 28, 2011). "In tribute to Corwin Hansch, father of QSAR". J Comput Aided Mol Des. 25 (6): 491. Bibcode:2011JCAMD..25..491M. doi:10.1007/s10822-011-9449-6. PMID 21710390.
  10. ^ Fujita, Toshio (June 22, 2011). "In memoriam professor Corwin Hansch: birth pangs of QSAR before 1961". J Comput Aided Mol Des. 25 (6): 509–517. Bibcode:2011JCAMD..25..509F. doi:10.1007/s10822-011-9450-0. PMID 21695492. S2CID 9840489.
  11. ^ Marino, M. (2004). "Biography of Jennifer A. Doudna". Proceedings of the National Academy of Sciences. 101 (49): 16987–9. Bibcode:2004PNAS..10116987M. doi:10.1073/pnas.0408147101. PMC 535403. PMID 15574498.
  12. ^ "[WorldCat search - books authored, edited, contributed]". WorldCat. Retrieved August 5, 2016.
  13. ^ "281 articles, author search". Pubmed. Retrieved 5 August 2016.
  14. ^ "33 authored reviews". Pubmed. Retrieved 5 August 2016.
  15. ^ "title word Pubmed records". PubMed. Retrieved 5 August 2016.

External links