EDIL3

Protein-coding gene in the species Homo sapiens

EGF like repeats and discoidin domains 3 is a protein that in humans is encoded by the EDIL3 gene.^[5]

Function

The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior.

References

1. GRCh38: Ensembl release 89: ENSG00000164176 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034488 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: EGF like repeats and discoidin domains 3". Retrieved 2017-07-24.

Further reading

• Rezaee M, Penta K, Quertermous T (2002). "Del1 mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3)". Am. J. Physiol. Heart Circ. Physiol. 282 (5): H1924–32. doi:10.1152/ajpheart.00921.2001. PMID 11959660.
• Aoka Y, Johnson FL, Penta K, Hirata Ki K, Hidai C, Schatzman R, Varner JA, Quertermous T (2002). "The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation". Microvascular Research. 64 (1): 148–61. doi:10.1006/mvre.2002.2414. PMID 12074641.
• Niu JX, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN (2007). "The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion". Eur. J. Cancer Prev. 16 (6): 517–27. doi:10.1097/CEJ.0b013e3280145c00. PMID 18090124. S2CID 1825380.
• Zou X, Qiao H, Jiang X, Dong X, Jiang H, Sun X (2009). "Downregulation of developmentally regulated endothelial cell locus-1 inhibits the growth of colon cancer". J. Biomed. Sci. 16 (1): 33. doi:10.1186/1423-0127-16-33. PMC 2666667. PMID 19292890.
• Johnson MP, Roten LT, Dyer TD, East CE, Forsmo S, Blangero J, Brennecke SP, Austgulen R, Moses EK (2009). "The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations". Hum. Genet. 126 (5): 655–66. doi:10.1007/s00439-009-0714-x. PMC 2783187. PMID 19578876.
• Bozaoglu K, Curran JE, Stocker CJ, Zaibi MS, Segal D, Konstantopoulos N, Morrison S, Carless M, Dyer TD, Cole SA, Goring HH, Moses EK, Walder K, Cawthorne MA, Blangero J, Jowett JB (2010). "Chemerin, a novel adipokine in the regulation of angiogenesis". J. Clin. Endocrinol. Metab. 95 (5): 2476–85. doi:10.1210/jc.2010-0042. PMC 2869547. PMID 20237162.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Sun JC, Liang XT, Pan K, Wang H, Zhao JJ, Li JJ, Ma HQ, Chen YB, Xia JC (2010). "High expression level of EDIL3 in HCC predicts poor prognosis of HCC patients". World J. Gastroenterol. 16 (36): 4611–5. doi:10.3748/wjg.v16.i36.4611. PMC 2945496. PMID 20857535.
• Glessner JT, Bradfield JP, Wang K, Takahashi N, Zhang H, Sleiman PM, Mentch FD, Kim CE, Hou C, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Zhao J, Chiavacci RM, Li M, Buxbaum JD, Berkowitz RI, Hakonarson H, Grant SF (2010). "A genome-wide study reveals copy number variants exclusive to childhood obesity cases". Am. J. Hum. Genet. 87 (5): 661–6. doi:10.1016/j.ajhg.2010.09.014. PMC 2978976. PMID 20950786.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.