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Human Antiviral for FIV Relief...?
I just want to check if any studies are out there for antiviral meds made for Humans have been able to help FIV positive symptoms and alleviate or help lessen negative effects of the virus? Please... I'm not looking for a miracle, just a little help. 2600:1002:A102:1B95:3656:86CD:4386:728C (talk) 01:19, 26 September 2023 (UTC)[reply]
@2600:1002:A102:1B95:3656:86CD:4386:728C: Sorry for the late response; been busy IRL. So I'm not a vet or doctor and this isn't medical advice, but I do have an FIV+ cat, so your question, of course, hits close to home. However, as a retrovirus (and specifically, a Lentivirus (so, same genus as HIV), the chances are pretty good anything that broadly affects retroviral and/or specifically lentiviral lifecycles could be good candidates. The downside, of course, is that FIV itself (much like HIV) doesn't directly cause the worst symptoms; usually the primary infection is nothing more than some flu symptoms that go away. It's what comes after the immune system is lowered. For example, in humans, HIV can lead to a condition where another virus causes Kaposi's sarcoma (KS), and once KS is established—even if HIV is brought entirely under control—the cancer that KS causes also has to be brought under control entirely separately (and, sadly, usually unsuccessfully; once you have disseminated KS, it's unlikely you'll live much longer). Similar situations can no doubt arise in felines with secondary infections.
Complicating things further, cats frequently have very different (and usually worse) tolerances for drugs than humans. A substance that humans can readily metabolize with their livers (or excrete with their kidneys) may be impossible for cats to handle and cause far more damage. For example, one of the now-PREP drugs involved in Truvada was/is used for antiviral purposes (hence why it's so useful for PREP). That drug is specifically bad for humans when they have pre-existing problems with their kidneys, so cats (notorious for eventual kidney problems, probably due to a high-protein diet) might be even more severely affected (I don't actually know; I'm just speculating). Long story short, treating/preventing HIV in humans can be problematic on its own, and the cross-species issues with physiology can be similarly so.
So I guess my answer is a "probably, but I have no idea, and I'd be extremely careful and instead enjoy what time you had/have left. Failing that, contact some vets and researchers that specialize in this sort of thing, if you can find them." You can try google scholar ([1]), but without a huge nerdy medical background, I probably wouldn't recommend trying to parse through it without expert help (it is extremely difficult to avoid scams and fake/bad/dangerous research if you aren't an expert).
I know it sucks. It really does. And I know it's not the answer you wanted to hear. Every day I worry about whether some random thing I bring inside might be the one thing that she can't handle, but it just makes every moment I do have with her that much more special. And if humans are indeed a benchmark in the immunodeficiency realm, me/us simply providing her/them a calm, stress-free environment to live in (rather than her former life on the streets) has kept her alive far longer than she ever would have been otherwise. I try to count that was a win, even though I know our time might be shorter than it would have been had she been completely healthy.
Hope that helps in some small way. I genuinely wish I could be an expert in all things everything (and especially this), but, well, ya know.... :P
Best of luck. *hugs* =)
--slakr\ talk / 02:51, 1 December 2023 (UTC)[reply]
BAG membership
Hello. You are listed as a member of the Bot Approvals Group but it appears you may not be actively helping in this area anymore. Do you intend to return to BAG-related activity on Wikipedia, or are you happy to be removed from this list? — Martin (MSGJ · talk) 12:58, 14 December 2023 (UTC)[reply]
Just to let you know that I have now removed your name from the list of active BAG members. Thanks and best wishes — Martin (MSGJ · talk) 15:28, 10 January 2024 (UTC)[reply]
Usurpation requested
Hi.
Please, pay attention to this. --Mykola7 (talk) 18:15, 30 March 2024 (UTC)[reply]
You've got mail!
Hello, Slakr. Please check your email; you've got mail! Message added 17:12, 14 May 2024 (UTC). It may take a few minutes from the time the email is sent for it to show up in your inbox. You can remove this notice at any time by removing the {{You've got mail}} or {{ygm}} template.
– DreamRimmer (talk) 17:12, 14 May 2024 (UTC)[reply]
Oh great...
Now that disruptive IP is at it again on Smalljim's talk page. NoobThreePointOh (talk) 08:23, 14 June 2024 (UTC)[reply]
SineBot down?
SineBot appears to be down (it last edited on May 2). Would you be able to investigate? Thanks, HouseBlaster (talk · he/they) 01:31, 15 June 2024 (UTC)[reply]
Apologies... I wasn't paying attention and I apparently need to verify the texting number it uses (that I'd normally get as a notification when it dies). :P --slakr\ talk / 06:07, 17 June 2024 (UTC)[reply]
I was wondering why @SineBot was down. There’s been a couple people on a big discussion (about F/EF5 tornadoes) on one of my WikiProjects that have forgotten to sign stuff and SineBot never signed any of the comments. West Virginia WXeditor (talk) 01:53, 19 July 2024 (UTC)[reply]
Ideally, please use this link to post new messages at the bottom. If you can't find something you recently posted, I might have moved it down there or it could have been archived if you posted it over 7 days ago. Cheers :)
