1921 in Argentine football saw Huracán winning its first Asociación Argentine title while Racing Club won the dissident Asociación Amateur championship.[1]
Banfield disaffiliated from the association moving to the rival Asociación Amateurs de Football with a few fixtures disputed.[2]
Racing Club won its 8th title. General Mitre, which had debuted at Primera after promoting last year, was expelled from the association after playing 17 fixtures and all its matches annulled.