The 1999–2000 Vyshcha Liha season was the 9th since its establishment. FC Dynamo Kyiv were the defending champions.
Note: the 1998–99 Ukrainian First League was won by the second team of Dynamo Kyiv, FC Dynamo-2 Kyiv, which could not be promoted. The third placed team FC Torpedo Zaporizhzhia was originally also had to be promoted, but due to its financial situation it filed for bankruptcy. Because of the situation with Torpedo, the Professional Football League of Ukraine scheduled a playoff game which was won by Prykarpattia.
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