Alfonso de Aragón y de Escobar (1417–1495), created Count of Cortes in 1462 by Queen Bianca of Navarre and later Count of Ribagorza in 1469, was advanced as 1st Duke of Villahermosa in 1476; married in 1477, Leonor de Sotomayor; in addition to illegitimate offspring, he had two sons and one daughter (Fernando (died 1483), Alfonso and Mariana), and was succeeded by his younger son:
Alfonso de Aragón y Sotomayor (1479–1513), 2nd Duke of Villahermosa: one illegitimate daughter, Leonor; succeeded by his sister.
Ferdinando Sanseverino y de Aragón (18 January 1507 – 1572), 4th Prince of Salerno (s. 1508) and 3rd Duke of Villahermosa (s. 1513). Was exiled in France from 1554 because King Charles I attainted him, forfeiting his titles and lands in Spain and Italy because of his services to the French Crown. The 4th Duke's sister was Laura Sanseverino de Aragón who married the Italo-Spanish condottiero, Ignacio de Avalos, 1st Marquess del Vasto.
Martín de Aragón y de Sarmiento (Pedrola, 1525–Zaragoza, 1581), 3rd Duke of Luna, 4th Duke of Villahermosa succeeded his cousin Ferdinando Sanseverino y de Aragón in 1554 by Royal Decree of King Charles I; he married at Medina Sidonia, in 1541, Luisa de Borja, (Gandía, 1529 - Zaragoza, 1560).
Fernando de Aragón y Borja, 5th Duke of Villahermosa (1546–1592).
Francisco de Aragón y Borja, Count of Luna, 6th Duke of Villahermosa (dukedom attainted).
Maria Luisa de Aragón, 7th Duchess of Villahermosa (1603–1663).
Fernando Manuel de Aragón, 8th Duke of Villahermosa (1663–1665).