List of liquid–liquid phase separation databases

Liquid-liquid phase separation (LLPS) is well defined in the Biomolecular condensate page.

LLPS databases cover different aspects of LLPS phenomena, ranging from cellular location of the Membraneless Organelles (MLOs) to the role of a particular protein/region forming the condensate state. These databases contain manually curated data supported by experimental evidence in the literature and can include related features as presence of protein disorder, low complexity, post-translational modifications, experimental details, phase diagrams, among others.

See also

• Biomolecular condensate

• MobiDB database

• Intrinsically disordered proteins

• DisProt database

References

1. You, Kaiqiang; Huang, Qi; Yu, Chunyu; Shen, Boyan; Sevilla, Cristoffer; Shi, Minglei; Hermjakob, Henning; Chen, Yang; Li, Tingting (2019-10-04). "PhaSepDB: a database of liquid–liquid phase separation related proteins". Nucleic Acids Research. 48 (D1): D354–D359. doi:10.1093/nar/gkz847. ISSN 0305-1048. PMC 6943039. PMID 31584089.
2. Hou, Chao; Xie, Haotai; Fu, Yang; Ma, Yao; Li, Tingting (2020-10-30). "MloDisDB: a manually curated database of the relations between membraneless organelles and diseases". Briefings in Bioinformatics. 22 (4). doi:10.1093/bib/bbaa271. ISSN 1467-5463. PMID 33126250.
3. Mészáros, Bálint; Erdős, Gábor; Szabó, Beáta; Schád, Éva; Tantos, Ágnes; Abukhairan, Rawan; Horváth, Tamás; Murvai, Nikoletta; Kovács, Orsolya P; Kovács, Márton; Tosatto, Silvio C E (2019-10-15). "PhaSePro: the database of proteins driving liquid–liquid phase separation". Nucleic Acids Research. 48 (D1): D360–D367. doi:10.1093/nar/gkz848. ISSN 0305-1048. PMC 7145634. PMID 31612960.
4. Li, Qian; Peng, Xiaojun; Li, Yuanqing; Tang, Wenqin; Zhu, Jia’an; Huang, Jing; Qi, Yifei; Zhang, Zhuqing (2019-09-06). "LLPSDB: a database of proteins undergoing liquid–liquid phase separation in vitro". Nucleic Acids Research. 48 (D1): D320–D327. doi:10.1093/nar/gkz778. ISSN 0305-1048. PMC 6943074. PMID 31906602.
5. Ning, Wanshan; Guo, Yaping; Lin, Shaofeng; Mei, Bin; Wu, Yu; Jiang, Peiran; Tan, Xiaodan; Zhang, Weizhi; Chen, Guowei; Peng, Di; Chu, Liang (2020-01-08). "DrLLPS: a data resource of liquid–liquid phase separation in eukaryotes". Nucleic Acids Research. 48 (D1): D288–D295. doi:10.1093/nar/gkz1027. ISSN 0305-1048. PMC 7145660. PMID 31691822.