Defending champion Roger Federer defeated Ivan Ljubičić in the final, 7–6(7–5), 7–6(7–4), 7–6(8–6) to win the men's singles tennis title at the 2006 Miami Open. With the win, Federer achieved his second Sunshine Double (following 2005).
All seeded players receive a bye into the second round.
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Roger Federer (champion)
Rafael Nadal (second round)
David Nalbandian (semifinals)
Andy Roddick (quarterfinals)
Nikolay Davydenko (fourth round)
Ivan Ljubičić (final) Guillermo Coria (third round) Gastón Gaudio (second round) James Blake (quarterfinals) David Ferrer (semifinals)
Richard Gasquet (second round).svg/1280px-Flag_of_Australia_(converted).svg.png){kind=small}
Lleyton Hewitt (second round) Juan Carlos Ferrero (second round)
Radek Štěpánek (fourth round)
Nicolas Kiefer (fourth round)
Dominik Hrbatý (second round)
Fernando González (third round) Sébastien Grosjean (third round) Robby Ginepri (third round) Tommy Robredo (second round) Mario Ančić (quarterfinals)
Jarkko Nieminen (third round) Igor Andreev (third round)
Marcos Baghdatis (third round) Tomáš Berdych (third round) Tommy Haas (third round) Gaël Monfils (second round).svg/1280px-Flag_of_Belgium_(civil).svg.png){kind=small}
Olivier Rochus (fourth round)
Filippo Volandri (third round) Fernando Verdasco (third round) Juan Ignacio Chela (fourth round)