Andrey Rublev defeated Félix Auger-Aliassime in the final, 7–5, 7–6(7–4) to win the singles title at the 2022 Open 13 Provence.
Daniil Medvedev was the defending champion,[1] but chose not to defend his title.
The top four seeds received a bye into the second round.
Stefanos Tsitsipas (quarterfinals)
Andrey Rublev (champion).svg/1280px-Flag_of_Canada_(Pantone).svg.png){kind=small}
Félix Auger-Aliassime (final) Aslan Karatsev (quarterfinals)
Ilya Ivashka (quarterfinals)
Tallon Griekspoor (first round).svg/1280px-Flag_of_Australia_(converted).svg.png){kind=small}
Alexei Popyrin (first round)
Gianluca Mager (withdrew)
Benjamin Bonzi (semifinals)
Tomáš Macháč (qualified)
Damir Džumhur (qualified) Roman Safiullin (qualified)
Mikhail Kukushkin (qualified).svg/1280px-Flag_of_Belgium_(civil).svg.png){kind=small}
Zizou Bergs (qualifying competition, lucky loser) Flavio Cobolli (first round).svg/1280px-Flag_of_Switzerland_(Pantone).svg.png){kind=small}
Marc-Andrea Hüsler (qualifying competition)
Lukáš Lacko (first round)