Panagiotis Kefalas (Greek: Παναγιώτης Κεφάλας) was a Greek fighter of the Greek War of Independence.
He hailed from Dirrachi in the Androusa province, but was unrelated to the Kefalas magnate family. He took part in several battles of the Greek War of Independence, from the capture of Kalamata and Karytaina to the Battle of Valtetsi and the Siege of Tripolitsa, where he commanded a Tsakonian detachment with distinction. He also fought against Mahmud Dramali Pasha in 1822, and in Continental Greece.
He fell at the Battle of Maniaki in 1825.