Chemical compound
Actinorhodin is a benzoisochromanequinone dimer polyketide antibiotic produced by Streptomyces coelicolor.[1][2] The gene cluster responsible for actinorhodin production contains the biosynthetic enzymes and genes responsible for export of the antibiotic.[3] The antibiotic also has the effect of being a pH indicator due to its pH-dependent color change.[4]
References
- ^ Magnolo SK, Leenutaphong DL, DeModena JA, et al. (May 1991). "Actinorhodin production by Streptomyces coelicolor and growth of Streptomyces lividans are improved by the expression of a bacterial hemoglobin". Bio/Technology. 9 (5): 473–6. doi:10.1038/nbt0591-473. PMID 1367312. S2CID 21623645.
- ^ Brian P, Riggle PJ, Santos RA, Champness WC (June 1996). "Global negative regulation of Streptomyces coelicolor antibiotic synthesis mediated by an absA-encoded putative signal transduction system". J. Bacteriol. 178 (11): 3221–31. doi:10.1128/jb.178.11.3221-3231.1996. PMC 178074. PMID 8655502.
- ^ Tahlan, K; Ahn SK; Sing A; Bodnaruk TD; Willems AR; Davidson AR; Nodwell JR. (February 2007). "Initiation of actinorhodin export in Streptomyces coelicolor". Molecular Microbiology. 63 (4): 951–961. doi:10.1111/j.1365-2958.2006.05559.x. PMID 17338074.
- ^ Bystrykh, LV; Fernández-Moreno MA; Herrema JK; Malpartida F; Hopwood DA; Dijkhuizen L (April 1996). "Production of actinorhodin-related "blue pigments" by Streptomyces coelicolor A3(2)". Journal of Bacteriology. 178 (8): 2238–44. doi:10.1128/jb.178.8.2238-2244.1996. PMC 177931. PMID 8636024.
