The Netherlands Football League Championship 1950–1951 was contested by 60 teams participating in five divisions. The national champion would be determined by a play-off featuring the winners of each division of the Netherlands. PSV Eindhoven won this year's championship by beating DWS, Willem II, Blauw-Wit Amsterdam and sc Heerenveen.
At the end of this season, the KNVB re-aligned the current system of Divisions into 4 new Divisions for 1951–52, to be called Eerste Klasse A-D.
This season, there was one division less than in the last one; this meant that all teams had to be reassigned.
Eerste Klasse A:
Eerste Klasse B:
Eerste Klasse C:
Eerste Klasse D:
Eerste Klasse E:
