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Diacetyl monoxime

Diacetyl monoxime is a chemical compound described by the formula CH3C(O)C(NOH)CH3. This colourless solid is the monooxime derivative of the diketone butane-2,3-dione (also known as diacetyl and biacetyl). Its biological effects include inhibiting certain ATPases.[1]

Preparation

The compound can be prepared from butanone by reaction with ethyl nitrite. It is an intermediate in the preparation of dimethylglyoxime:[2]

Uses

Diacetyl monoxime can be used with thiosemicarbazide to selectively detect small amounts of urea in the presence of other nitrogen-containing compounds.[3]

References

  1. ^ Forer, Arthur; Fabian, Lacramioara (2005). "Does 2,3-butanedione monoxime inhibit nonmuscle myosin?". Protoplasma. 225 (1–2): 1–4. doi:10.1007/s00709-004-0077-z. PMID 15868207. S2CID 10475777.
  2. ^ Semon, W. L.; Damerell, V. R. (1930). "Dimethylglyoxime". Organic Syntheses. 10: 22. doi:10.15227/orgsyn.010.0022.
  3. ^ Douglas, L. A.; Bremner, J. M. (1970-02-01). "Colorimetric Determination of Microgram Quantities of Urea". Analytical Letters. 3 (2): 79–87. doi:10.1080/00032717008067782. ISSN 0003-2719.