Ferroxidase

Iron oxidizing enzyme, Fe(II) to Fe(III) conversion

Ferroxidase also known as Fe(II):oxygen oxidoreductase is an enzyme that catalyzes the oxidization of iron II to iron III:

4 Fe²⁺ + 4 H⁺ + O₂ ⇔ 4 Fe³⁺ + 2H₂O

Examples

Human genes encoding proteins with ferroxidase activity include:

• CP – Ceruloplasmin
• FTH1 – Ferritin heavy chain
• FTMT – Ferritin, mitochondrial
• HEPH - Hephaestin

References

• Cox JC, Boxer DH (1986). "The role of rusticyanin, a blue copper protein, in the electron transport chain of Thiobacillus ferrooxidans grown on iron or thiosulfate". Biotechnol. Appl. Biochem. 8: 269–275.
• Osaki S (November 1966). "Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase (ceruloplasmin)". J. Biol. Chem. 241 (21): 5053–9. doi:10.1016/S0021-9258(18)99669-9. PMID 5925868.
• Osaki S, Walaas O (June 1967). "Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase. II. Rate constants at various steps and formation of a possible enzyme-substrate complex". J. Biol. Chem. 242 (11): 2653–7. doi:10.1016/S0021-9258(18)99620-1. PMID 6027241.