Anthramycin, the first PBD monomer, was first synthesized in the 1960s.[2]
References
^Hartley JA (June 2011). "The development of pyrrolobenzodiazepines as antitumour agents". Expert Opinion on Investigational Drugs. 20 (6): 733–44. doi:10.1517/13543784.2011.573477. PMID 21457108. S2CID 26275418.
^Mantaj, Julia; Jackson, Paul J. M.; Rahman, Khondaker M.; Thurston, David E. (2017). "From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody–Drug Conjugates (ADCs)". Angewandte Chemie International Edition. 56 (2): 462–488. doi:10.1002/anie.201510610. PMC 5215561. PMID 27862776.