Chemical compound
Pargyline (brand name Eutonyl) is an irreversible selective monoamine oxidase (MAO)-B inhibitor drug (IC50 for MAO-A is 11.52 nM and for MAO-B is 8.20 nM)[1][2] It was brought to market in the US and the UK by Abbott in 1963 as an antihypertensive drug branded "Eutonyl". It was one of several MAO inhibitors introduced in the 1960s including nialamide, isocarboxazid, phenelzine, and tranylcypromine.[3][4][5][6] By 2007 the drug was discontinued[7] and as of 2014[update] there were no generic versions available in the US.[8] In addition to its actions as an MAOI, pargyline has been found to bind with high affinity to the I2 imidazoline receptor (an allosteric site on the MAO enzyme).[9]
See also
References
- ^ Fisar Z, Hroudová J, Raboch J (2010). "Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers". Neuro Endocrinology Letters. 31 (5): 645–656. PMID 21200377.
- ^ Murphy DL, Karoum F, Pickar D, et al. (1998). "Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (Clorgyline) or MAO-B (Selegiline and pargyline)". In Finberg JP, Youdim MB, Riederer P, Tipton KF (eds.). MAO — the Mother of all Amine Oxidases. Journal of Neural Transmission Supplementum. Vol. 52. pp. 39–48. doi:10.1007/978-3-7091-6499-0_5. ISBN 978-3-211-83037-6. PMID 9564606.
- ^ Shorter E (2005). A Historical Dictionary of Psychiatry. Oxford University Press. p. 146. ISBN 0195176685.
- ^ Wardell WM, Lasagna L (1975). Regulation Drug Development. Evaluative Studies. Vol. 21. American Enterprise Institute. p. 60. ISBN 0844731676.
- ^ Council on Drugs' Statements (1963). "New Drugs and Developments in Therapeutics: Pargyline Hydrochloride (Eutonyl)". JAMA. 184 (11): 887. doi:10.1001/jama.1963.03700240079013.
- ^ "Eutonyl and MAO inhibitors". Drug and Therapeutics Bulletin. 1 (15): 59–60. 15 November 1963. doi:10.1136/dtb.1.15.59. ISSN 1755-5248. S2CID 220162992.
Pargyline is promoted only for the treatment of hypertension, and not for depression.
- ^ Pray WS (2007). "Interactions Between Nonprescription Products and Psychotropic Medications". US Pharmacist. 32 (11): 12–15.
- ^ "Eutonyl". Drugs@FDA Database. U.S. Food and Drug Administration (FDA). Retrieved July 19, 2014.
- ^ Piletz JE, Halaris A, Ernsberger PR (1995). "Psychopharmacology of imidazoline and α2-adrenergic receptors: implications for depression". Critical Reviews in Neurobiology. 9 (1). CRC Press: 29–66 (43). PMID 8828003.
